It's easier to dissect differences when talking about two specific engines, identified by engine code, vehicle model, and vehicle model year. Looking at the US 3.0T, there's 7 different engine codes [CCA, CCB, CGX, CTU, CJW, CTW, CRE] across 11 different model bases [C6.5 A6, C7.0 A6/A7, C7.5 A6/A7, D4.0 A8, D4.5 A8, B8.0 S4/S5, B8.5 S4/S5, B8.5 Q5, B8.5 SQ5, E1.5 Q7, E1.5 Q7 S-line].
I've already posted a chart I made of the different 3.0Ts in the US market models,
https://www.audizine.com/forum/showt...1#post14320929
You can see the first response, "I replaced my B8.0 S4 CAKA (so probably EU market) with the Q7 CJT". But he doesn't elaborate which CJT (only one is 333hp), and still comments "plug and play, well, except this and that". The this and that is important.
I assume the particulars of swapping the engines native to the B8 S4, [CCBA, CGXC, CTUB], is already known. Similar to "sure, you can move that 2013 CAEB in place of your 2010 CAEB, so long as you move your old 2-pin crank position sensor over". So even when it's the same engine code in the same model, there can be little details that have to be known.
When Audi added dual injection to the EA888 2.0T for EU emissions changes, the US versions do not include them. The CRE has the same port injection addition for EU emissions; did the CREC in the US A8/A6/A7/A8 retain the dual injection system? I imagine even if you added all the wiring, the S4 ECU wouldn't know what to do with a CREC engine.
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