I have been doing a lot of research on this subject, and will share what I know so far. I don't have time at work right now to upload photos, but will later.
1. RS4 calipers are eight pistons, same as RS6. They are expensive, and judging by their complete failure when Champion used RS6's in the speed series (against Alcon, and Stoptech equipped cars) they may not be the hot ticket.
2. Cayenne calipers are available to fit 330 and 350mm rotors. I will concentrate on the 350's, because I assume everybody wants bigger. Side note: I corresponded with someone from eastern europe who was using the 330mm calipers with rear rotors from a Cayenne, which have less material than a front rotor should for absorbing heat and may warp or crack under hard use.
3. Hubcentricity. Any Porsche or MB rotor will not be centered on the Audi hub and will require redrilling to 112mm (Porsche). This may cause balance issues, so I believe that the correct solution is a VAG-specific rotor.
4. There was a person on here who was selling what appeared in photos to be a 345mm rotors that was the correct offset for this application. He didn't show pads in the caliper, so I have no idea whether the pads may hang over the edge of the rotor by 2.5mm (difference in radius between 350 and 345mm) They were clearly from a VAG application. If the pads do hang over slightly, it may not be much of a problem, or I could have the top arc of the pads shaved off by a machine shop.
5. AFAIK, the only applications of 345mm rotors on VAG products are B6/B7 S4, R32 (same as S4), Brembo-equipped 2001-ish S8, and Passat W8. All of these are different part numbers, except the S4/R32, which are compatible. I have a couple of photos of a B7 S4 with Cayenne calipers where a buddy of the owner said that they went right on, with correct offset and no spacers or custom work. I have purchased an extra S4 steering knuckle, and have some B6 S4 rotors at home to experiment with this combo.
6. Staggered piston sizes. Because the Cayenne has calipers on the leading edge of the rotor, and the S4 has them on the trailing edge, the way that others (including ECS)have gotten around this is to mount the right caliper on the left side and vice-versa.
The bores are staggered in size to combat uneven temperatures across the surface of a large pad, which can lead to fade, and taper problems with pads over time and lots of use. Brembo designed the staggered bore sizes that way on purpose, and I believe the best way to maintain this is to keep the caliper on the correct side, but to swap the bleeders for the connector pipe. Note: Q7 and Cayenne calipers can do this, but Touareg calipers will not- the connector pipe is internal to the Touareg caliper.
7. Lines. I'd use lines for a Brembo-equipped Audi like a 2001 S8. One can get oe or aftermarket braided lines for this application.
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